Friday, January 27, 2012

Batman, Hebrew, and Genesis

The semester at BYU following my mission was an exploratory one. I left on my mission knowing that I did not want to continue in the major I started in. However, as I returned I didn't know what major to choose, so I decided to have a little bit of fun. I had always been interested in the facsimiles of the Book of Abraham, so I took a Pearl of Great Price (PofGP) class from Michael Rhodes because he was the only religion professor that I knew could translate them. At the same time I took an introductory class in biblical Hebrew. My Hebrew was never advanced; I did alright in the class, but the height of my ability was to translate some very simple sentences.

One day in PofGP class, I realized that there were honest-to-goodness Hebrew words in the Book of Abraham. Words like Kokob, Kokaubeam, and Shaumahyeem were words that I was learning in my Hebrew class. I also knew enough Church history to know that Joseph Smith had studied Hebrew in Kirtland. At some point it occurred to me that the reason there were Hebrew words in the Book of Abraham was probably because Joseph had studied Hebrew, not because they were revealed to him.

It turns out that, of course, I'm not the only one to have noticed this. For example, a 1981 article in Sunstone, "Professor Seixas, the Hebrew Bible, and the Book of Abraham," explains how wording in the Book of Abraham creation account reflects Joseph's studies of Hebrew. In some cases, the word choices are more aligned with the Hebrew text of Genesis than the Book of Moses, which was Joseph's inspired, pre-Hebrew, rendition of the same material. At a minimum this calls into question simplistic notions that any of these versions represent the original text. Over at Times and Seasons, Ben S. is posting notes for his Institute class where he lays out the same basic argument. He makes some great points, and I suggest you go read what he has to say.

So how do the Genesis, the Book of Moses, Book of Abraham, and temple creation accounts relate to each other? I think it's obvious that the Genesis text is the touchstone for the rest. But why have more than one? I'm chewing on a different way of thinking about them, and here's where Batman comes in.

Compare the 1989 movie Batman (with Michael Keaton and Jack Nicholson) to The Dark Night (with Christian Bale and Heath Ledger). Both movies cover the same basic story--the battle between Batman and the Joker--but do so with different details and interpretation of character. If you broaden the scope to include the various television series and comic books, you see a variety of interpretations of Batman, but they remain unified by constant elements of his character. Similar things could be said of the James Bond movies; there is a certain consistency between the movies with respect to the characters and elements of the storyline. However, there is usually not any attempt to maintain continuity between movies. Or if we switch to music, we could speak of different versions of the same jazz song, or re-mixes of pop songs. In each case the movie or song stands on its own, while at the same time being intimately tied to others.

That's kind of how I view the various creation accounts. Each is a re-mix of the Genesis story, but with novel elements that reflect Joseph's changing understanding and sensibilities, which gives each a different flavor. In this view, the question of which version is the "correct" or "original" is largely irrelevant. Each stands on its own, but you can't get too attached to the details because they are flexible.



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Thursday, January 19, 2012

The Book of Mormon as a Quasispecies

Sometimes it's fun to find commonality between otherwise unrelated things.

One of the problems faced by all organisms is the need to replicate their genetic code with fidelity. Too many mutation can be lethal. The enzymes that replicate genomes occasionally make errors, and many organisms have proof-reading enzymes that help to identify and correct mistakes. However, many viruses, such as HIV, get by without this proof-reading ability. In fact, the lack of proof-reading is actually advantageous to them because mutations help to keep them nimble in the face of the onslaught of the immune system.

If you were to chemically synthesize the genome of one of these viruses (so that you knew the precise genetic sequence), introduce it into a host, and then sequence the genomes of the progeny virus. You would find lots of variants from the original genome sequence. In fact, there is a sense in which the virus does not have a single genome sequence. Rather, the virus exists as a cloud of variant sequences called a 'quasispecies.'

The quasispecies concept is a model rooted in mathematics, and although many virologists are familiar with the term, my sense is that most don't really understand the mathematical underpinnings. (Neither do I.) Nevertheless, the quasispecies model has interesting implications. Some mutations are advantageous and some are deleterious, and we usually think of natural selection as weeding out unfit individuals and promoting the more fit ones. However, in the quasispecies model selection acts on the cloud of variants as a unit, and it's possible for a cloud of less-fit genomes to out-compete a single, more-fit genome. And if you were to align the sequences of all of the individual genomes and create a consensus sequence by using a majority vote at each position, you might find that the consensus sequence is not represented in any individual genome.

The 1830 edition of the Book of Mormon is kind of like a quasispecies because it turns out that it is not a single text. As the sheets were being printed, mistakes--both human and mechanical--were noticed and corrected. At least 41 changes are known. However, the already printed sheets were not discarded, and so there was a mixing of mistakes which were scattered throughout the 5,000 finished copies. It's possible that you could come up with a consensus text that is not found in any single copy.

There's no profound meaning here--I guess that's about the extent of the similarities. I just figured that introducing the quasispecies concept along with Book of Mormon trivia was more fun than doing them independently.


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Wednesday, January 11, 2012

CES? I Don't Think So



What? Consumer Electronics Show? Nevermind.


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Friday, January 06, 2012

Spend an Evening with Daniel Peterson

It's been a little while since I've checked in on the Mormon Stories podcast, and boy have I been missing out. Today I want to highlight a 4-part interview with Daniel C. Peterson. That works out to about 4.5 hours of discussion with one of the Church's chief (if not the chief) apologists. It's a wide-ranging and pretty frank discussion, and I thought it was just delightful. Here are a few of the gems that I picked out:

- He has an abiding interest in astronomy, cosmology, and geology. In fact, he originally intended to be a cosmologist.

- A desire that we teach our history better (i.e. warts and all), and that Sunday school in general be improved. In connection with this, Peterson tells some amusing stories about his time on the Sunday school manual-writing committee.

- While serving as a gospel doctrine teacher, he talked about the human side of prophets (e.g. Nephi probably was a really annoying younger brother). A contingent of the class complained to their bishop that he was teaching "secular humanism."

- Speaking of humanism, Peterson sees Mormonism as a kind of theistic humanism, and thinks that non-religious humanists have important things to say.

- His opinion that many prophecies, and their fulfillment, are often a reflection of God's power to bring things to pass in the way he chooses, rather than some kind of predestined future.

- A second-hand story that President Eyring remarked that most high priest groups have more doctrinal certainty than the First Presidency.

I want to dwell on one part of the interview for a moment, because I think it needs some challenging. In defense of Joseph Smith's use of folk-magic, Peterson pointed out that dowsing for water is still a wide-spread practice, and told of a personal experience where dowsing for water seemed to work. First I should note that although that line of defense might work well with religious critics, it makes things worse for someone of a scientific skepticism orientation. This is because dowsing appears to be a phenomenon that can be attributed to subconscious cues and muscle movements, and retrospective justification. In short, it appears to be a psychological illusion, similar to facilitated communication and Ouija boards.

I don't doubt Peterson's sincerity (and to be clear, he does not claim that dowsing does in fact work), nor am I in a position to judge his experience, but his story does raise some red flags. For example, he and others may have received subtle cues as to where the water pipe was. Did the dowsing rods cross at exactly the right spot, or was there an element of 'close enough,' that artificially inflates the number of hits? Further, Peterson discounts the guy for whom the dowsing failed, attributing the failure to his not holding it right. As convincing as the experience sounds, a lot of ordinary possibilities remain. So, I agree that Joseph's use of folk-magic is not, in and of itself, any more scandalous than dowsing, but let's be careful in comparing him to a practice that controlled tests have repeatedly shown to be illusory. (Actually, I'm open to the possibility that many of Joseph's magical experiences were honest illusions, but that's another discussion.)

Anyway, my overall impression of the discussion is that Daniel Peterson and I think a lot alike, and his view of Mormonism resonates with me in many ways. I don't say that as though he should be flattered or to inflate my own status. I simply mean that Peterson has impeccable LDS credentials, so when I agree with him about something that isn't the company line, so to speak, I think I'm in good company.

In the spirit of this blog, I want to finish with a couple of quotes that I really liked.

To the extent that there is an anti-scientific, anti-intellectual strain in CES [the Church Educational System], that's something that needs to be rooted out. This does not help us. And I know that there is a movement on in the Church right now with some people pushing certain geographical theories of the Book of Mormon, and a component of that is young-earth creationism, anti-evolutionism. This worries me enormously, because it can't be sustained.

And later:
We're not fundamentalist Protestants who happen to have an extra book, and maybe an extra wife.

...Mormonism itself is bigger than that. And I object to it when critics try to paint us as a narrow-minded little fundamentalist sect, and I really object to it when Mormons try to do it. And I don't like it from either side. That's why I object to some of this young-earth creationist stuff that I'm hearing recently. No, no, that's not us.

Preach it, brother!


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Wednesday, December 28, 2011

If I Had a Side Blog (#5)

I've got most of the week off, but haven't felt like doing much blogging. So here is some stuff to chew on for the time being.

1. Did Jesus have long hair?

2. Why energy journalism is so bad.

3. Do facts exist anymore? And can they be checked?

4. Although this is about Gingrich, it speaks to a larger issue: underappreciation of the importance of public health infrastructure.

5. We are apparently to the point where imaginary objects are security threats.

6. Kevin Drum about sums it up:

Climate change is the public policy problem from hell. If you were inventing a problem that would be virtually impossible to solve, you'd give it all the characteristics of climate change: it's largely invisibile, it's slow moving, it's expensive to fix, it requires global coordination, and its effects will be disproportionately borne by poor countries that nobody cares about.


7. I have some serious career envy.




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Thursday, December 22, 2011

XMRV Paper Retracted

Earlier this month I highlighted the drama and controversy surrounding the claim that a virus (XMRV) was associated with chronic fatigue syndrome. The original paper has now been fully retracted by Science.


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Sunday, December 18, 2011

Theology and Non-Mortal Biology

A new article in Dialogue: A Journal of Mormon Thought has attracted attention in the bloggernacle. The article, "Toward a Post-Heterosexual Mormon Theology," by Taylor G. Petrey, is a discussion of how LDS theology might one day incorporate homosexual relationships. However, even if homosexuality is not a topic that interests you, this article is still worth reading if you ever think about how mortal biology fits into the grand scheme of things. Two of the main topics treated are reproduction and gender. Let's look briefly at each one.

Reproduction

Petrey begins his discussion of reproduction by noting that we have competing notions of how spirits are created. Joseph Smith emphasized the eternal nature of intelligence (D&C 93:29–33), and it appears that notions of "spirit birth" came later, following his death [1].

The ambivalence on this point is a persistent tension in Mormon thought. That is, the doctrine of spiritual birth stands at odds with the doctrine of eternal intelligences, and to this day Mormonism has not resolved this tension. On the one hand, “spirit birth” is a divine reproduction that mirrors human reproduction, requiring a male and female partner; and on the other hand, “spirit birth” is a more metaphorical “organization” that bears little resemblance to reproduction as a result of sexual intercourse.

Sometimes it is emphasized that we are "literally" children of God. Adding in the word "literally," however, doesn't clear up the questions. A friend of mine had parents who divorced when he was young, and his mother re-married soon after. As far as my friend was concerned, the second man--what we would call his step-father--was his father, period. My friend wasn't LDS, but we could imagine that he was and that this reconstituted family was sealed together in the temple--an imaginary situation that reflects a common reality. Under these circumstances, was the second man literally my friend's father? What does that question even mean? The problem here is that fatherhood (and by implication, childhood) has several fascets to it, with a source of genetic information being only one of them. That's why we have to tack on words like 'biological', 'adopted', and 'step' when not all of the fascets are contained in a single relationship.

To say that I am a spirit child of God is to say something important. But like Petrey seems to, I have trouble connecting it too closely to mortal biology--as though spirit gametes fuse to form a spirit embryo containing spirit DNA from each parent, which then implants in a spirit womb and grows until one day it is ready to come out--with all of this somehow happening inside an immortal physical body. Here I see a connection to Petrey's discussion of sealing as building kinship. Whatever else may be involved (or not) in both my spiritual and physical creation, I see my relationship with God, along with my future potential and eternal destiny, as the defining feature of my existence--both past and future. I'm not wedded to any particular explanation of how that relationship came about. "I know that [God] loveth his children; nevertheless, I do not know the meaning of all things [1 Nephi 11:17]."

Petrey also notes that it seems strange that mortals pair to bring spirits into mortality, but that somehow it requires two immortal bodies to create spirits, which are two stages back in progression. In connection with this, I've noticed a similar puzzle: according to some commentators Adam and Eve were physically created by the union of two immortal bodies. This would seem to imply that immortal reproductive organs have a dual usage--creation of both physical bodies and spirits, depending on...well, who knows what?

Gender

The article devotes several pages to a discussion of gender. Although we are taught that gender is an eternal part of our identity, the word itself has a somewhat ambiguous meaning, and it isn't clear how it maps onto the premortal life. This is part of a larger problem hinted at above: The closer spirit form and creation is tied to mortal biology, the sillier it starts to sound in light of what we know about biology (especially genetics), and a sort of predestination seems needed to solve some of the consequent problems [2]. Further, Petrey notes:
The whole question of the relationship of the premortal spirit to the mortal body is at stake in the claim that “gender” belongs to both equally. If any of the particularities of one’s genetic and environmental circumstances may be said to not preexist with a particular spirit in a deterministic way, why then is sexual difference the exception? To assert that “gender” is more fundamental to one’s identity than these other contingent features begs the question: Of the many different features of human identity, why does sexual difference—whatever that may refer to—occupy a privileged place in the account of the eternal nature of the human being?

In other words, we know a lot about how genes determine hair color, skin color, and so on. Can any of these features be said to correspond to our premortal spirit, and if not, then why gender? And although it is easy to dismiss intersex individuals as exceptions to the rule (victims of "pranks of nature," to use the term of a couple of Church leaders), such an attitude papers over the multiple layers and plasticity of sexual development [3].

Petrey is not the first to notice these kinds of issues [4], but I think he has done a good job of explaining and expressing them. I don't expect any change in the way the Church approaches the issues discussed in the article, but at a minimum it serves as a good reminder that as clear as we think our doctrines are, they are embedded in a matrix of unnoticed assumptions and unanswered questions, some of which are probably the result of having a doctrinal structure that was mostly in place before the foundations of the sciences as we know them. And you never know--many people concluded that the priesthood ban didn't make sense, and that it had a dubious history, years before it was ended. Although its removal was a matter of revelation, it appears that scholarship helped to clear the path for the revelation [5]. I like to think that D&C 9:7-8 operates for both individuals and institutions, and that seems to be what Petrey is aiming for.

Notes:

1. Blake Ostler, "The Idea of Pre-existence in the Development of Mormon Thought"

2. Such explanations don't really explain anything, either. See The Spirit as a Homunculus.

3. See Duane Jeffery's article, "Intersexes in Humans," for a nice LDS-oriented discussion of this topic. It seems to have held up well since it's publication in 1979. See also Jeffrey Keller, "Is Sexual Gender Eternal?"

4. For example, see Kent Condie, "Premortal Spirits: Implications for Cloning, Abortion, Evolution, and Extinction."

5. Edward Kimball, Lengthen Your Stride: The Presidency of Spencer W. Kimball, p. 219-220.
On May 25, Mark E. Petersen called President Kimball's attention to an article that proposed the priesthood policy had begun with Brigham Young, not Joseph Smith, and he suggested that the President might wish to consider this factor.




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Saturday, December 03, 2011

Real-Life Science Drama

I'm late on this, but I'm guessing most people haven't paid attention to it anyway, so it's just as well. And as you'll see at the end, it's a story that hasn't finished.

In 2009 a paper was published in Science that reported an association between chronic fatigue syndrome (CFS) and a retrovirus called XMRV. Although it was premature at the time to say that XMRV caused CFS, once it was shown that XMRV was sensitive to anti-retroviral drugs used in HIV treatment, some patients started taking the drugs in an attempt to treat CFS, and patient advocacy groups rallied around the new CFS paradigm. Further, there was concern that XMRV might be in the blood supply, prompting the exclusion of donors with CFS.

However, there is mounting evidence that the claims of the original paper were not correct, with other groups repeatedly failing to confirm the results, the original group unable to reliably identify positive samples, and evidence that the virus itself is a laboratory product. Last May Science suggested that the original paper be retracted, but the authors refused. So the editor, Bruce Alberts, published an "expression of concern" which essentially said that Science no longer had confidence in the paper. Fast forward to September: the authors of the original study retracted several figures from the paper when they determined that the results were based on contaminated samples. A week later lead author Judy Mikovits was fired, apparently over a dispute about sharing of cell lines.

The XMRV history is mostly laid out in "False Positive", published in Science, but it's behind a paywall. However, the LA Times had a good story that covers much of the same material. It's fascinating to read as the evidence for the hypothesis is described, and then to watch the tide turn against what seemed like compelling findings. Mix in Mikovits digging her heels in--going so far as to claim conspiracy against her--and the hysterics of patient-advocacy groups (physically threatening scientists, in some cases), and you've got a real scientific drama.

But beyond the drama, this story helps to illuminate how science works. Philosopher Karl Popper famously argued that science works by falsification. It's not uncommon (at least in Internet discussions) to hear this view strictly applied--that it only takes a single experiment to falsify a theory. But this example shows that it isn't so simple. The impact of a single experiment depends on context, technology, and the state of the field. When contradictory results are obtained, it takes time to gain clarity. Right now it looks like the XMRV link to CFS is dead. However, Mikovits still believes that a link exists and that the difficulties in nailing it down can be attributed to the biology of the virus-host interaction. Is that ad hoc rationalization in an attempt to save a favored hypothesis, or is it perseverance in the face of a complex world that doesn't always give easy answers?

This, in turn, gives us an opportunity to think about Thomas Kuhn's notion of paradigms and what it means to know something based on collected knowledge. Going forward, the notion that XMRV or any other retrovirus causes CFS will be viewed with great skepticism by most scientists, and this collective judgment will dominate the field, while a few dedicated (intransigent?) researchers may soldier on. I don't think that CFS is prevalent enough to catch public attention like, say, vaccines have, but you never know. Will we hear complaints that the dominant view is held by closed-minded defenders of the status quo? Will the minority attempt to wrap themselves in the clothes of Galileo?

The latest is that Mikovits has been charged with two felonies in Nevada and is the subject of a civil suit from her former employer over the removal of laboratory notebooks and attempts to send materials to another lab.

It's been a roller-coaster ride so far, and it looks like the ride isn't over yet.

(In addition to links in the post, also see here.)

[Update, 12/22/11: The original paper has been fully retracted.]


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