Wednesday, December 28, 2011

If I Had a Side Blog (#5)

I've got most of the week off, but haven't felt like doing much blogging. So here is some stuff to chew on for the time being.

1. Did Jesus have long hair?

2. Why energy journalism is so bad.

3. Do facts exist anymore? And can they be checked?

4. Although this is about Gingrich, it speaks to a larger issue: underappreciation of the importance of public health infrastructure.

5. We are apparently to the point where imaginary objects are security threats.

6. Kevin Drum about sums it up:

Climate change is the public policy problem from hell. If you were inventing a problem that would be virtually impossible to solve, you'd give it all the characteristics of climate change: it's largely invisibile, it's slow moving, it's expensive to fix, it requires global coordination, and its effects will be disproportionately borne by poor countries that nobody cares about.


7. I have some serious career envy.




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Thursday, December 22, 2011

XMRV Paper Retracted

Earlier this month I highlighted the drama and controversy surrounding the claim that a virus (XMRV) was associated with chronic fatigue syndrome. The original paper has now been fully retracted by Science.


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Sunday, December 18, 2011

Theology and Non-Mortal Biology

A new article in Dialogue: A Journal of Mormon Thought has attracted attention in the bloggernacle. The article, "Toward a Post-Heterosexual Mormon Theology," by Taylor G. Petrey, is a discussion of how LDS theology might one day incorporate homosexual relationships. However, even if homosexuality is not a topic that interests you, this article is still worth reading if you ever think about how mortal biology fits into the grand scheme of things. Two of the main topics treated are reproduction and gender. Let's look briefly at each one.

Reproduction

Petrey begins his discussion of reproduction by noting that we have competing notions of how spirits are created. Joseph Smith emphasized the eternal nature of intelligence (D&C 93:29–33), and it appears that notions of "spirit birth" came later, following his death [1].

The ambivalence on this point is a persistent tension in Mormon thought. That is, the doctrine of spiritual birth stands at odds with the doctrine of eternal intelligences, and to this day Mormonism has not resolved this tension. On the one hand, “spirit birth” is a divine reproduction that mirrors human reproduction, requiring a male and female partner; and on the other hand, “spirit birth” is a more metaphorical “organization” that bears little resemblance to reproduction as a result of sexual intercourse.

Sometimes it is emphasized that we are "literally" children of God. Adding in the word "literally," however, doesn't clear up the questions. A friend of mine had parents who divorced when he was young, and his mother re-married soon after. As far as my friend was concerned, the second man--what we would call his step-father--was his father, period. My friend wasn't LDS, but we could imagine that he was and that this reconstituted family was sealed together in the temple--an imaginary situation that reflects a common reality. Under these circumstances, was the second man literally my friend's father? What does that question even mean? The problem here is that fatherhood (and by implication, childhood) has several fascets to it, with a source of genetic information being only one of them. That's why we have to tack on words like 'biological', 'adopted', and 'step' when not all of the fascets are contained in a single relationship.

To say that I am a spirit child of God is to say something important. But like Petrey seems to, I have trouble connecting it too closely to mortal biology--as though spirit gametes fuse to form a spirit embryo containing spirit DNA from each parent, which then implants in a spirit womb and grows until one day it is ready to come out--with all of this somehow happening inside an immortal physical body. Here I see a connection to Petrey's discussion of sealing as building kinship. Whatever else may be involved (or not) in both my spiritual and physical creation, I see my relationship with God, along with my future potential and eternal destiny, as the defining feature of my existence--both past and future. I'm not wedded to any particular explanation of how that relationship came about. "I know that [God] loveth his children; nevertheless, I do not know the meaning of all things [1 Nephi 11:17]."

Petrey also notes that it seems strange that mortals pair to bring spirits into mortality, but that somehow it requires two immortal bodies to create spirits, which are two stages back in progression. In connection with this, I've noticed a similar puzzle: according to some commentators Adam and Eve were physically created by the union of two immortal bodies. This would seem to imply that immortal reproductive organs have a dual usage--creation of both physical bodies and spirits, depending on...well, who knows what?

Gender

The article devotes several pages to a discussion of gender. Although we are taught that gender is an eternal part of our identity, the word itself has a somewhat ambiguous meaning, and it isn't clear how it maps onto the premortal life. This is part of a larger problem hinted at above: The closer spirit form and creation is tied to mortal biology, the sillier it starts to sound in light of what we know about biology (especially genetics), and a sort of predestination seems needed to solve some of the consequent problems [2]. Further, Petrey notes:
The whole question of the relationship of the premortal spirit to the mortal body is at stake in the claim that “gender” belongs to both equally. If any of the particularities of one’s genetic and environmental circumstances may be said to not preexist with a particular spirit in a deterministic way, why then is sexual difference the exception? To assert that “gender” is more fundamental to one’s identity than these other contingent features begs the question: Of the many different features of human identity, why does sexual difference—whatever that may refer to—occupy a privileged place in the account of the eternal nature of the human being?

In other words, we know a lot about how genes determine hair color, skin color, and so on. Can any of these features be said to correspond to our premortal spirit, and if not, then why gender? And although it is easy to dismiss intersex individuals as exceptions to the rule (victims of "pranks of nature," to use the term of a couple of Church leaders), such an attitude papers over the multiple layers and plasticity of sexual development [3].

Petrey is not the first to notice these kinds of issues [4], but I think he has done a good job of explaining and expressing them. I don't expect any change in the way the Church approaches the issues discussed in the article, but at a minimum it serves as a good reminder that as clear as we think our doctrines are, they are embedded in a matrix of unnoticed assumptions and unanswered questions, some of which are probably the result of having a doctrinal structure that was mostly in place before the foundations of the sciences as we know them. And you never know--many people concluded that the priesthood ban didn't make sense, and that it had a dubious history, years before it was ended. Although its removal was a matter of revelation, it appears that scholarship helped to clear the path for the revelation [5]. I like to think that D&C 9:7-8 operates for both individuals and institutions, and that seems to be what Petrey is aiming for.

Notes:

1. Blake Ostler, "The Idea of Pre-existence in the Development of Mormon Thought"

2. Such explanations don't really explain anything, either. See The Spirit as a Homunculus.

3. See Duane Jeffery's article, "Intersexes in Humans," for a nice LDS-oriented discussion of this topic. It seems to have held up well since it's publication in 1979. See also Jeffrey Keller, "Is Sexual Gender Eternal?"

4. For example, see Kent Condie, "Premortal Spirits: Implications for Cloning, Abortion, Evolution, and Extinction."

5. Edward Kimball, Lengthen Your Stride: The Presidency of Spencer W. Kimball, p. 219-220.
On May 25, Mark E. Petersen called President Kimball's attention to an article that proposed the priesthood policy had begun with Brigham Young, not Joseph Smith, and he suggested that the President might wish to consider this factor.




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Saturday, December 03, 2011

Real-Life Science Drama

I'm late on this, but I'm guessing most people haven't paid attention to it anyway, so it's just as well. And as you'll see at the end, it's a story that hasn't finished.

In 2009 a paper was published in Science that reported an association between chronic fatigue syndrome (CFS) and a retrovirus called XMRV. Although it was premature at the time to say that XMRV caused CFS, once it was shown that XMRV was sensitive to anti-retroviral drugs used in HIV treatment, some patients started taking the drugs in an attempt to treat CFS, and patient advocacy groups rallied around the new CFS paradigm. Further, there was concern that XMRV might be in the blood supply, prompting the exclusion of donors with CFS.

However, there is mounting evidence that the claims of the original paper were not correct, with other groups repeatedly failing to confirm the results, the original group unable to reliably identify positive samples, and evidence that the virus itself is a laboratory product. Last May Science suggested that the original paper be retracted, but the authors refused. So the editor, Bruce Alberts, published an "expression of concern" which essentially said that Science no longer had confidence in the paper. Fast forward to September: the authors of the original study retracted several figures from the paper when they determined that the results were based on contaminated samples. A week later lead author Judy Mikovits was fired, apparently over a dispute about sharing of cell lines.

The XMRV history is mostly laid out in "False Positive", published in Science, but it's behind a paywall. However, the LA Times had a good story that covers much of the same material. It's fascinating to read as the evidence for the hypothesis is described, and then to watch the tide turn against what seemed like compelling findings. Mix in Mikovits digging her heels in--going so far as to claim conspiracy against her--and the hysterics of patient-advocacy groups (physically threatening scientists, in some cases), and you've got a real scientific drama.

But beyond the drama, this story helps to illuminate how science works. Philosopher Karl Popper famously argued that science works by falsification. It's not uncommon (at least in Internet discussions) to hear this view strictly applied--that it only takes a single experiment to falsify a theory. But this example shows that it isn't so simple. The impact of a single experiment depends on context, technology, and the state of the field. When contradictory results are obtained, it takes time to gain clarity. Right now it looks like the XMRV link to CFS is dead. However, Mikovits still believes that a link exists and that the difficulties in nailing it down can be attributed to the biology of the virus-host interaction. Is that ad hoc rationalization in an attempt to save a favored hypothesis, or is it perseverance in the face of a complex world that doesn't always give easy answers?

This, in turn, gives us an opportunity to think about Thomas Kuhn's notion of paradigms and what it means to know something based on collected knowledge. Going forward, the notion that XMRV or any other retrovirus causes CFS will be viewed with great skepticism by most scientists, and this collective judgment will dominate the field, while a few dedicated (intransigent?) researchers may soldier on. I don't think that CFS is prevalent enough to catch public attention like, say, vaccines have, but you never know. Will we hear complaints that the dominant view is held by closed-minded defenders of the status quo? Will the minority attempt to wrap themselves in the clothes of Galileo?

The latest is that Mikovits has been charged with two felonies in Nevada and is the subject of a civil suit from her former employer over the removal of laboratory notebooks and attempts to send materials to another lab.

It's been a roller-coaster ride so far, and it looks like the ride isn't over yet.

(In addition to links in the post, also see here.)

[Update, 12/22/11: The original paper has been fully retracted.]


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